Assay Detail
Functional
CHEMBL971707
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by alamar blue assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.23 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL497306 | — | — | 1 | 7.28 |
| CHEMBL497477 | — | — | 1 | 7.20 |
| CHEMBL445813 | AT-7519 | 2.0 | 1 | 7.09 |
| CHEMBL498659 | — | — | 1 | 6.89 |
| CHEMBL507167 | — | — | 1 | 6.60 |
| CHEMBL457388 | — | — | 1 | 6.51 |
| CHEMBL457177 | — | — | 1 | 6.50 |
| CHEMBL456963 | — | — | 1 | 6.26 |
| CHEMBL448316 | — | — | 1 | 6.04 |
| CHEMBL518383 | — | — | 1 | 5.85 |
| CHEMBL510578 | — | — | 1 | 5.68 |
| CHEMBL463579 | — | — | 1 | 5.47 |
| CHEMBL463580 | — | — | 1 | 5.41 |
| CHEMBL443198 | — | — | 1 | 4.48 |
| CHEMBL457208 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL497306 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL497477 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL445813 | AT-7519 | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL498659 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL507167 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL457388 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL457177 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL456963 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL448316 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL518383 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL510578 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL463579 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL463580 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL443198 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL457208 | — | IC50 | - | — | - |