Assay Detail
Functional
CHEMBL971730
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Induction of apoptosis in human HCT116 cells assessed as caspase 3 activation after 24 hrs
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a potent inducer of apoptosis with high in vivo activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 7.20 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444724 | — | — | 1 | 8.70 |
| CHEMBL457612 | — | — | 1 | 8.30 |
| CHEMBL512022 | — | — | 1 | 8.10 |
| CHEMBL456790 | — | — | 1 | 7.89 |
| CHEMBL458063 | — | — | 1 | 7.82 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.82 |
| CHEMBL442575 | — | — | 1 | 7.68 |
| CHEMBL500814 | — | — | 1 | 7.54 |
| CHEMBL458062 | — | — | 1 | 7.51 |
| CHEMBL456789 | — | — | 1 | 7.31 |
| CHEMBL457838 | — | — | 1 | 7.23 |
| CHEMBL457628 | — | — | 1 | 7.19 |
| CHEMBL457846 | — | — | 1 | 7.14 |
| CHEMBL505530 | — | — | 1 | 6.92 |
| CHEMBL512029 | — | — | 1 | 6.92 |
| CHEMBL457396 | — | — | 1 | 6.52 |
| CHEMBL511514 | — | — | 1 | 6.46 |
| CHEMBL492325 | — | — | 1 | 6.34 |
| CHEMBL513771 | — | — | 1 | 6.01 |
| CHEMBL456788 | — | — | 1 | 5.96 |
| CHEMBL458061 | — | — | 1 | 5.85 |
| CHEMBL456157 | — | — | 1 | - |
| CHEMBL458032 | — | — | 1 | - |
| CHEMBL457613 | — | — | 1 | - |
| CHEMBL456373 | — | — | 1 | - |
| CHEMBL456374 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444724 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL457612 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL512022 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL456790 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL458063 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL107 | COLCHICINE | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL442575 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL500814 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL458062 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL456789 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL457838 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL457628 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL457846 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL505530 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL512029 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL457396 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL511514 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL492325 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL513771 | — | EC50 | = | 970.0 | nM | 6.01 |
| CHEMBL456788 | — | EC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL458061 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL456157 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL458032 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL457613 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL456373 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL456374 | — | EC50 | > | 10000.0 | nM | - |