Assay Detail
Binding
CHEMBL971817
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Inhibition of phosphorylated KDR by HTRF assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and biological evaluation of potent c-Met inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.80 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL460772 | — | — | 1 | 7.25 |
| CHEMBL447602 | — | — | 1 | 7.08 |
| CHEMBL453737 | — | — | 1 | 6.86 |
| CHEMBL461831 | — | — | 1 | 6.42 |
| CHEMBL505896 | — | — | 1 | 6.38 |
| CHEMBL461648 | — | — | 1 | - |
| CHEMBL444560 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL460772 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL447602 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL453737 | — | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL461831 | — | Ki | = | 382.0 | nM | 6.42 |
| CHEMBL505896 | — | Ki | = | 422.0 | nM | 6.38 |
| CHEMBL461648 | — | Ki | > | 1300.0 | nM | - |
| CHEMBL444560 | — | Ki | > | 3000.0 | nM | - |