Compound Detail
CHEMBL460772
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Basic Information
| ChEMBL ID | CHEMBL460772 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KOSDHWQYVDNUML-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
467.5
MW (Da)
6.23
ALogP
6
HBA
0
HBD
66.4
PSA (Ų)
0.28
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 7.25
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | Ki | 7.25 | 7.25 | 56.0 | 1 |
| Macrophage-stimulating protein receptor CHEMBL2689 | Ki | 7.1 | 7.1 | 79.0 | 1 |
| Hepatocyte growth factor receptor CHEMBL3717 | Ki | 6.7 | 6.7 | 201.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | Ki | = | 56.0 | nM | 7.25 | Inhibition of phosphorylated KDR by HTRF assay | 18763753 |
| Macrophage-stimulating protein receptor | Ki | = | 79.0 | nM | 7.1 | Inhibition of phosphorylated RON | 18763753 |
| Hepatocyte growth factor receptor | Ki | = | 201.0 | nM | 6.7 | Inhibition of cMet by HTRF assay | 18763753 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18763753 | 10.1021/jm8006189 | Vascular endothelial growth factor receptor 2 | 1 |
| 18763753 | 10.1021/jm8006189 | Macrophage-stimulating protein receptor | 1 |
| 18763753 | 10.1021/jm8006189 | Hepatocyte growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine