Assay Detail
Binding
CHEMBL971822
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of phosphorylated RON
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Macrophage-stimulating protein receptor (CHEMBL2689) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and biological evaluation of potent c-Met inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.11 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL447602 | — | — | 1 | 8.89 |
| CHEMBL453737 | — | — | 1 | 7.55 |
| CHEMBL460772 | — | — | 1 | 7.10 |
| CHEMBL461831 | — | — | 1 | 7.10 |
| CHEMBL505896 | — | — | 1 | 6.71 |
| CHEMBL461648 | — | — | 1 | 6.24 |
| CHEMBL444560 | — | — | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL447602 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL453737 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL460772 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL461831 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL505896 | — | Ki | = | 195.0 | nM | 6.71 |
| CHEMBL461648 | — | Ki | = | 581.0 | nM | 6.24 |
| CHEMBL444560 | — | Ki | = | 706.0 | nM | 6.15 |