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Assay Detail

CHEMBL972078

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Functional
Cytotoxicity against human A431 cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A-431
Confidence 1 — Organism
Curated By Autocuration

Target

A-431 (CHEMBL614069)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological evaluation of analogues of cryptolepine, an alkaloid isolated from the Suriname rainforest.
Yang SW, Abdel-Kader M, Malone S, Werkhoven MC, Wisse JH, Bursuker I, Neddermann K, Fairchild C, Raventos-Suarez C, Menendez AT, Lane K, Kingston DG.
J Nat Prod (1999) 62 : 976 -983
PubMed 10425120 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 6.47 6.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL172017 1 6.47
CHEMBL491341 1 6.47

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL172017 IC50 = 340.0 nM 6.47
CHEMBL491341 IC50 = 340.0 nM 6.47