Assay Detail
Functional
CHEMBL972281
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Inhibition of glucose-induced insulin secretion in Wistar rat pancreatic beta islets assessed as residual insulin secretion relative to control
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
New R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylaminothiocarbonylamino)-2H-1-benzopyrans structurally related to (+/-)-cromakalim as tissue-selective pancreatic beta-cell K(ATP) channel openers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.53 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112668 | — | — | 1 | 6.14 |
| CHEMBL447283 | — | — | 1 | 5.65 |
| CHEMBL497955 | — | — | 1 | 5.64 |
| CHEMBL497954 | — | — | 1 | 5.59 |
| CHEMBL497956 | — | — | 1 | 5.56 |
| CHEMBL526087 | — | — | 1 | 5.51 |
| CHEMBL451698 | — | — | 1 | 5.49 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 4.65 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | 4.0 | 1 | - |
| CHEMBL49035 | CROMAKALIM | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112668 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL447283 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL497955 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL497954 | — | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL497956 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL526087 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL451698 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL181 | DIAZOXIDE | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | IC50 | > | 100000.0 | nM | - |
| CHEMBL49035 | CROMAKALIM | IC50 | > | 100000.0 | nM | - |