Assay Detail
Binding
CHEMBL972319
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF-28 from human cloned sst4 receptor expressed in CCL39 cells
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CCL39 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Ring size of somatostatin analogues (ODT-8) modulates receptor selectivity and binding affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.63 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL446380 | — | — | 1 | 9.15 |
| CHEMBL504087 | — | — | 1 | 9.05 |
| CHEMBL500326 | — | — | 1 | 9.00 |
| CHEMBL504457 | — | — | 1 | 8.89 |
| CHEMBL504248 | — | — | 1 | 8.85 |
| CHEMBL503036 | — | — | 1 | 8.82 |
| CHEMBL447989 | — | — | 1 | 8.80 |
| CHEMBL452157 | — | — | 1 | 8.74 |
| CHEMBL505128 | — | — | 1 | 8.72 |
| CHEMBL504395 | — | — | 1 | 8.70 |
| CHEMBL506892 | — | — | 1 | 8.66 |
| CHEMBL524870 | — | — | 1 | 8.59 |
| CHEMBL501776 | — | — | 1 | 8.59 |
| CHEMBL505496 | — | — | 1 | 8.57 |
| CHEMBL453936 | — | — | 1 | 8.52 |
| CHEMBL525030 | — | — | 1 | 8.51 |
| CHEMBL505854 | — | — | 1 | 8.49 |
| CHEMBL442494 | — | — | 1 | 8.47 |
| CHEMBL504462 | — | — | 1 | 8.36 |
| CHEMBL503596 | — | — | 1 | 8.35 |
| CHEMBL502511 | — | — | 1 | 8.30 |
| CHEMBL525397 | — | — | 1 | 8.22 |
| CHEMBL502777 | — | — | 1 | 8.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL446380 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL504087 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL500326 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL504457 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL504248 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL503036 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL447989 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL452157 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL505128 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL504395 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL506892 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL524870 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL501776 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL505496 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL453936 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL525030 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL505854 | — | IC50 | = | 3.25 | nM | 8.49 |
| CHEMBL442494 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL504462 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL503596 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL502511 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL525397 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL502777 | — | IC50 | = | 8.2 | nM | 8.09 |