Compound Detail
CHEMBL504248
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CC(=O)N[C@H]1CCSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O
Basic Information
| ChEMBL ID | CHEMBL504248 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | HZNDTCHPXXGRFB-LRVFNMPTSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
1135.4
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 8.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 4 CHEMBL1853 | IC50 | 8.85 | 8.85 | 1.4 | 1 |
| Somatostatin receptor type 2 CHEMBL1804 | IC50 | 7.4 | 7.4 | 40.0 | 1 |
| Somatostatin receptor type 3 CHEMBL2028 | IC50 | 7.16 | 7.16 | 69.0 | 1 |
| Somatostatin receptor type 5 CHEMBL1792 | IC50 | 7.05 | 7.05 | 90.0 | 1 |
| Somatostatin receptor type 1 CHEMBL1917 | IC50 | 6.66 | 6.66 | 218.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 4 | IC50 | = | 1.4 | nM | 8.85 | Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF-28 from human cloned sst4 recep... | 18410084 |
| Somatostatin receptor type 2 | IC50 | = | 40.0 | nM | 7.4 | Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF-28 from human cloned sst2 recep... | 18410084 |
| Somatostatin receptor type 3 | IC50 | = | 69.0 | nM | 7.16 | Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF-28 from human cloned sst3 recep... | 18410084 |
| Somatostatin receptor type 5 | IC50 | = | 90.0 | nM | 7.05 | Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF-28 from human cloned sst5 recep... | 18410084 |
| Somatostatin receptor type 1 | IC50 | = | 218.0 | nM | 6.66 | Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF28 from human cloned sst1 recept... | 18410084 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18410084 | 10.1021/jm701444y | Somatostatin receptor type 1 | 1 |
| 18410084 | 10.1021/jm701444y | Somatostatin receptor type 2 | 1 |
| 18410084 | 10.1021/jm701444y | Somatostatin receptor type 3 | 1 |
| 18410084 | 10.1021/jm701444y | Somatostatin receptor type 4 | 1 |
| 18410084 | 10.1021/jm701444y | Somatostatin receptor type 5 | 1 |
Data from ChEMBL 36 via Core Engine