Assay Detail
Binding
CHEMBL972423
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of lipid-modified (octylated) form of SHH expressed in mouse s12 cells by luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Hedgehog-Gli signaling pathway inhibitors as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.65 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL480889 | — | — | 1 | 7.00 |
| CHEMBL186779 | JERVINE | — | 1 | 6.30 |
| CHEMBL473189 | — | — | 1 | - |
| CHEMBL515092 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL480889 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL186779 | JERVINE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL473189 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL515092 | — | IC50 | < | 100.0 | nM | - |