Assay Detail
Binding
CHEMBL972431
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Gli1-mediated transcription expressed in human PANC1 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | PANC-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Hedgehog-Gli signaling pathway inhibitors as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.38 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL504404 | PHYSALIN B | — | 1 | 6.21 |
| CHEMBL1215434 | PHYSALIN F | — | 1 | 6.18 |
| CHEMBL16958 | STAUROSPORINONE | — | 1 | 5.75 |
| CHEMBL193468 | — | — | 1 | 5.75 |
| CHEMBL95476 | ARCYRIAFLAVIN C | — | 1 | 5.75 |
| CHEMBL190546 | — | — | 1 | 5.75 |
| CHEMBL245412 | ZERUMBONE | — | 1 | 5.15 |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | 4.50 |
| CHEMBL470503 | COLUBRINIC ACID | — | 1 | 4.42 |
| CHEMBL511805 | ALPHITOLIC ACID | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL504404 | PHYSALIN B | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL1215434 | PHYSALIN F | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL16958 | STAUROSPORINONE | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL193468 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL95476 | ARCYRIAFLAVIN C | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL190546 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL245412 | ZERUMBONE | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL269277 | BETULINIC ACID | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL470503 | COLUBRINIC ACID | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL511805 | ALPHITOLIC ACID | IC50 | = | 42000.0 | nM | 4.38 |