Compound Detail
CHEMBL95476
ARCYRIAFLAVIN C Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL95476 |
| Name | ARCYRIAFLAVIN C |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | COUUDSNRXUXNDW-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
357.3
MW (Da)
3.25
ALogP
4
HBA
5
HBD
118.2
PSA (Ų)
0.27
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Zinc finger protein GLI1 CHEMBL5461 | IC50 | 5.75 | 5.75 | 1800.0 | 1 |
| Zinc finger protein GLI2 CHEMBL5119 | IC50 | 5.57 | 5.57 | 2700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Zinc finger protein GLI1 | IC50 | = | 1800.0 | nM | 5.75 | Inhibition of Gli1-mediated transcription expressed in human PANC1 cells | 19309080 |
| Zinc finger protein GLI2 | IC50 | = | 2700.0 | nM | 5.57 | Inhibition of Gli2-mediated transcription expressed in human PANC1 cells | 19309080 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14611848 | 10.1016/s0960-894x(03)00592-4 | HeLa | 2 |
| 17531487 | 10.1016/j.bmcl.2007.05.033 | Unchecked | 1 |
| 19309080 | 10.1021/jm801420y | Zinc finger protein GLI1 | 1 |
| 19309080 | 10.1021/jm801420y | Zinc finger protein GLI2 | 1 |
Data from ChEMBL 36 via Core Engine