Assay Detail
Binding
CHEMBL972432
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Inhibition of Gli2-mediated transcription expressed in human PANC1 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | PANC-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Hedgehog-Gli signaling pathway inhibitors as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.66 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245412 | ZERUMBONE | — | 1 | 6.04 |
| CHEMBL16958 | STAUROSPORINONE | — | 1 | 5.57 |
| CHEMBL193468 | — | — | 1 | 5.57 |
| CHEMBL95476 | ARCYRIAFLAVIN C | — | 1 | 5.57 |
| CHEMBL190546 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245412 | ZERUMBONE | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL16958 | STAUROSPORINONE | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL193468 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL95476 | ARCYRIAFLAVIN C | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL190546 | — | IC50 | = | 2700.0 | nM | 5.57 |