Assay Detail
Functional
CHEMBL972452
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense after 72 hrs by alamar blue assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Antiplasmodial and antitrypanosomal activity of bicyclic amides and esters of dialkylamino acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.90 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.41 |
| CHEMBL512069 | — | — | 1 | 6.89 |
| CHEMBL466437 | — | — | 1 | 6.85 |
| CHEMBL235333 | — | — | 1 | 6.68 |
| CHEMBL511209 | — | — | 1 | 6.64 |
| CHEMBL512241 | — | — | 1 | 6.57 |
| CHEMBL237458 | — | — | 1 | 6.50 |
| CHEMBL510747 | — | — | 1 | 6.46 |
| CHEMBL237613 | — | — | 1 | 6.43 |
| CHEMBL466095 | — | — | 1 | 6.39 |
| CHEMBL392520 | — | — | 1 | 6.25 |
| CHEMBL219073 | — | — | 1 | 6.22 |
| CHEMBL235539 | — | — | 1 | 6.21 |
| CHEMBL513643 | — | — | 1 | 6.16 |
| CHEMBL392519 | — | — | 1 | 6.14 |
| CHEMBL495021 | — | — | 1 | 6.07 |
| CHEMBL466497 | — | — | 1 | 6.06 |
| CHEMBL392729 | — | — | 1 | 6.06 |
| CHEMBL466108 | — | — | 1 | 5.95 |
| CHEMBL375182 | — | — | 1 | 5.94 |
| CHEMBL466107 | — | — | 1 | 5.80 |
| CHEMBL237612 | — | — | 1 | 5.70 |
| CHEMBL522353 | — | — | 1 | 5.56 |
| CHEMBL521525 | — | — | 1 | 5.38 |
| CHEMBL414705 | — | — | 1 | 5.18 |
| CHEMBL522683 | — | — | 1 | 4.55 |
| CHEMBL494152 | — | — | 1 | 4.51 |
| CHEMBL468130 | — | — | 1 | 4.50 |
| CHEMBL493558 | — | — | 1 | 4.39 |
| CHEMBL494024 | — | — | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL512069 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL466437 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL235333 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL511209 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL512241 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL237458 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL510747 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL237613 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL466095 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL392520 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL219073 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL235539 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL513643 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL392519 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL495021 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL466497 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL392729 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL466108 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL375182 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL466107 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL237612 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL522353 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL521525 | — | IC50 | = | 4150.0 | nM | 5.38 |
| CHEMBL414705 | — | IC50 | = | 6570.0 | nM | 5.18 |
| CHEMBL522683 | — | IC50 | = | 28250.0 | nM | 4.55 |
| CHEMBL494152 | — | IC50 | = | 30790.0 | nM | 4.51 |
| CHEMBL468130 | — | IC50 | = | 31930.0 | nM | 4.50 |
| CHEMBL493558 | — | IC50 | = | 41070.0 | nM | 4.39 |
| CHEMBL494024 | — | IC50 | = | 45800.0 | nM | 4.34 |
| CHEMBL493963 | — | IC50 | = | 92010.0 | nM | 4.04 |