Assay Detail
ADMET
CHEMBL972453
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Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiplasmodial and antitrypanosomal activity of bicyclic amides and esters of dialkylamino acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 4.40 | 5.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 5.11 |
| CHEMBL237613 | — | — | 1 | 4.85 |
| CHEMBL237458 | — | — | 1 | 4.79 |
| CHEMBL392520 | — | — | 1 | 4.62 |
| CHEMBL466437 | — | — | 1 | 4.61 |
| CHEMBL237612 | — | — | 1 | 4.53 |
| CHEMBL466497 | — | — | 1 | 4.53 |
| CHEMBL235539 | — | — | 1 | 4.52 |
| CHEMBL235333 | — | — | 1 | 4.49 |
| CHEMBL512241 | — | — | 1 | 4.46 |
| CHEMBL466095 | — | — | 1 | 4.42 |
| CHEMBL512069 | — | — | 1 | 4.40 |
| CHEMBL510747 | — | — | 1 | 4.39 |
| CHEMBL511209 | — | — | 1 | 4.37 |
| CHEMBL392519 | — | — | 1 | 4.31 |
| CHEMBL466108 | — | — | 1 | 4.30 |
| CHEMBL513643 | — | — | 1 | 4.24 |
| CHEMBL392729 | — | — | 1 | 4.22 |
| CHEMBL495021 | — | — | 1 | 4.21 |
| CHEMBL466107 | — | — | 1 | 4.18 |
| CHEMBL493558 | — | — | 1 | 4.16 |
| CHEMBL468130 | — | — | 1 | 4.12 |
| CHEMBL521525 | — | — | 1 | 4.06 |
| CHEMBL414705 | — | — | 1 | 4.05 |
| CHEMBL522353 | — | — | 1 | 4.02 |
| CHEMBL494024 | — | — | 1 | - |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | - |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | - |
| CHEMBL494152 | — | — | 1 | - |
| CHEMBL522683 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 7780.0 | nM | 5.11 |
| CHEMBL237613 | — | IC50 | = | 14220.0 | nM | 4.85 |
| CHEMBL237458 | — | IC50 | = | 16380.0 | nM | 4.79 |
| CHEMBL392520 | — | IC50 | = | 23920.0 | nM | 4.62 |
| CHEMBL466437 | — | IC50 | = | 24590.0 | nM | 4.61 |
| CHEMBL237612 | — | IC50 | = | 29260.0 | nM | 4.53 |
| CHEMBL466497 | — | IC50 | = | 29460.0 | nM | 4.53 |
| CHEMBL235539 | — | IC50 | = | 30140.0 | nM | 4.52 |
| CHEMBL235333 | — | IC50 | = | 32660.0 | nM | 4.49 |
| CHEMBL512241 | — | IC50 | = | 34950.0 | nM | 4.46 |
| CHEMBL466095 | — | IC50 | = | 38100.0 | nM | 4.42 |
| CHEMBL512069 | — | IC50 | = | 39860.0 | nM | 4.40 |
| CHEMBL510747 | — | IC50 | = | 40880.0 | nM | 4.39 |
| CHEMBL511209 | — | IC50 | = | 42940.0 | nM | 4.37 |
| CHEMBL392519 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL466108 | — | IC50 | = | 50240.0 | nM | 4.30 |
| CHEMBL513643 | — | IC50 | = | 57520.0 | nM | 4.24 |
| CHEMBL392729 | — | IC50 | = | 60390.0 | nM | 4.22 |
| CHEMBL495021 | — | IC50 | = | 61060.0 | nM | 4.21 |
| CHEMBL466107 | — | IC50 | = | 66190.0 | nM | 4.18 |
| CHEMBL493558 | — | IC50 | = | 69100.0 | nM | 4.16 |
| CHEMBL468130 | — | IC50 | = | 75430.0 | nM | 4.12 |
| CHEMBL521525 | — | IC50 | = | 86690.0 | nM | 4.06 |
| CHEMBL414705 | — | IC50 | = | 89740.0 | nM | 4.05 |
| CHEMBL522353 | — | IC50 | = | 94970.0 | nM | 4.02 |
| CHEMBL494024 | — | IC50 | = | 195400.0 | nM | - |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 188500.0 | nM | - |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 450500.0 | nM | - |
| CHEMBL494152 | — | IC50 | = | 119900.0 | nM | - |
| CHEMBL522683 | — | IC50 | = | 127800.0 | nM | - |
| CHEMBL493963 | — | IC50 | = | 177400.0 | nM | - |
| CHEMBL219073 | — | IC50 | = | 108800.0 | nM | - |
| CHEMBL375182 | — | IC50 | = | 120400.0 | nM | - |