Assay Detail
Functional
CHEMBL972499
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Reduction of chemotaxis in human neutrophils assessed as inhibition of fMLP-OMe-induced cell migration pretreated 10 mins before fMLP-OMe challenge
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.93 | 10.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 10.33 |
| CHEMBL466493 | — | — | 1 | 9.72 |
| CHEMBL507797 | — | — | 1 | 9.37 |
| CHEMBL467717 | — | — | 1 | 8.96 |
| CHEMBL450095 | — | — | 1 | 8.49 |
| CHEMBL466056 | — | — | 1 | 8.11 |
| CHEMBL468744 | — | — | 1 | 8.01 |
| CHEMBL466698 | — | — | 1 | 7.92 |
| CHEMBL468084 | — | — | 1 | 7.82 |
| CHEMBL466113 | — | — | 1 | 7.75 |
| CHEMBL512960 | — | — | 1 | 7.70 |
| CHEMBL512980 | — | — | 1 | 7.11 |
| CHEMBL467873 | — | — | 1 | 7.05 |
| CHEMBL467249 | — | — | 1 | 7.00 |
| CHEMBL505321 | — | — | 1 | 6.92 |
| CHEMBL513307 | — | — | 1 | 6.82 |
| CHEMBL466492 | — | — | 1 | 5.70 |
| CHEMBL468085 | — | — | 1 | - |
| CHEMBL512997 | — | — | 1 | - |
| CHEMBL468536 | — | — | 1 | - |
| CHEMBL468745 | — | — | 1 | - |
| CHEMBL468746 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 0.047 | nM | 10.33 |
| CHEMBL466493 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL507797 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL467717 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL450095 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL466056 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL468744 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL466698 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL468084 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL466113 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL512960 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL512980 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL467873 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL467249 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL505321 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL513307 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL466492 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL468085 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL512997 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL468536 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL468745 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL468746 | — | IC50 | > | 10.0 | nM | - |