Assay Detail
Functional
CHEMBL972500
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Reduction of chemotaxis in human neutrophils assessed as inhibition of IL8-induced cell migration pretreated 10 mins before IL8 challenge
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 8.71 | 10.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL513307 | — | — | 1 | 10.26 |
| CHEMBL467717 | — | — | 1 | 10.05 |
| CHEMBL468536 | — | — | 1 | 9.70 |
| CHEMBL466493 | — | — | 1 | 9.44 |
| CHEMBL512960 | — | — | 1 | 9.00 |
| CHEMBL466113 | — | — | 1 | 8.89 |
| CHEMBL450095 | — | — | 1 | 8.72 |
| CHEMBL466698 | — | — | 1 | 8.02 |
| CHEMBL226836 | — | — | 1 | 8.00 |
| CHEMBL226887 | — | — | 1 | 7.85 |
| CHEMBL226939 | — | — | 1 | 7.35 |
| CHEMBL450013 | — | — | 1 | 7.26 |
| CHEMBL467249 | — | — | 1 | - |
| CHEMBL512997 | — | — | 1 | - |
| CHEMBL468084 | — | — | 1 | - |
| CHEMBL468744 | — | — | 1 | - |
| CHEMBL467873 | — | — | 1 | - |
| CHEMBL468085 | — | — | 1 | - |
| CHEMBL507797 | — | — | 1 | - |
| CHEMBL505321 | — | — | 1 | - |
| CHEMBL468746 | — | — | 1 | - |
| CHEMBL512980 | — | — | 1 | - |
| CHEMBL466492 | — | — | 1 | - |
| CHEMBL466056 | — | — | 1 | - |
| CHEMBL468745 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL513307 | — | IC50 | = | 0.0546 | nM | 10.26 |
| CHEMBL467717 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL468536 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL466493 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL512960 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL466113 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL450095 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL466698 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL226836 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL226887 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL226939 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL450013 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL467249 | — | IC50 | = | 0.00055 | nM | - |
| CHEMBL512997 | — | IC50 | = | 0.0007 | nM | - |
| CHEMBL468084 | — | IC50 | = | 0.00054 | nM | - |
| CHEMBL468744 | — | IC50 | = | 0.00097 | nM | - |
| CHEMBL467873 | — | IC50 | = | 0.00082 | nM | - |
| CHEMBL468085 | — | IC50 | = | 0.00099 | nM | - |
| CHEMBL507797 | — | IC50 | = | 0.0032 | nM | - |
| CHEMBL505321 | — | IC50 | = | 0.0016 | nM | - |
| CHEMBL468746 | — | IC50 | = | 0.0074 | nM | - |
| CHEMBL512980 | — | IC50 | = | 0.0018 | nM | - |
| CHEMBL466492 | — | IC50 | = | 8e-05 | nM | - |
| CHEMBL466056 | — | IC50 | = | 0.0076 | nM | - |
| CHEMBL468745 | — | IC50 | = | 0.0042 | nM | - |