Assay Detail
Functional
CHEMBL972519
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human P-glycoprotein-expressing KBV1 cells after 72 hrs by MTT assay
37
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB-V1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 5.17 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443772 | — | — | 2 | 5.68 |
| CHEMBL470509 | — | — | 2 | 5.62 |
| CHEMBL504574 | — | — | 2 | 5.48 |
| CHEMBL492408 | — | — | 2 | 5.40 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 5.39 |
| CHEMBL474416 | — | — | 2 | 5.28 |
| CHEMBL495479 | — | — | 2 | 5.24 |
| CHEMBL231616 | TRIAPINE | 3.0 | 2 | 5.23 |
| CHEMBL489742 | — | — | 2 | 5.17 |
| CHEMBL474417 | — | — | 2 | 5.03 |
| CHEMBL376584 | — | — | 2 | 4.99 |
| CHEMBL523326 | — | — | 2 | 4.68 |
| CHEMBL474400 | — | — | 1 | 4.52 |
| CHEMBL390341 | — | — | 2 | 4.46 |
| CHEMBL523111 | — | — | 1 | - |
| CHEMBL489938 | — | — | 1 | - |
| CHEMBL333137 | — | — | 1 | - |
| CHEMBL514013 | — | — | 1 | - |
| CHEMBL444521 | — | — | 1 | - |
| CHEMBL525231 | — | — | 1 | - |
| CHEMBL491979 | — | — | 1 | - |
| CHEMBL491309 | — | — | 1 | - |
| CHEMBL375492 | AMITHIOZONE | 2.0 | 1 | - |
| CHEMBL326294 | ISATIN | — | 1 | - |
| CHEMBL493237 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443772 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL443772 | — | IC50 | = | 2089.3 | nM | 5.68 |
| CHEMBL470509 | — | IC50 | = | 2398.83 | nM | 5.62 |
| CHEMBL470509 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL504574 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL504574 | — | IC50 | = | 3311.31 | nM | 5.48 |
| CHEMBL492408 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL492408 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL535 | SUNITINIB | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL474416 | — | IC50 | = | 5248.07 | nM | 5.28 |
| CHEMBL474416 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL495479 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL495479 | — | IC50 | = | 5754.4 | nM | 5.24 |
| CHEMBL231616 | TRIAPINE | IC50 | = | 5888.44 | nM | 5.23 |
| CHEMBL231616 | TRIAPINE | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL489742 | — | IC50 | = | 6760.83 | nM | 5.17 |
| CHEMBL489742 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL474417 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL474417 | — | IC50 | = | 9332.54 | nM | 5.03 |
| CHEMBL376584 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL376584 | — | IC50 | = | 10232.93 | nM | 4.99 |
| CHEMBL523326 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL523326 | — | IC50 | = | 20892.96 | nM | 4.68 |
| CHEMBL474400 | — | IC50 | = | 30300.0 | nM | 4.52 |
| CHEMBL390341 | — | IC50 | = | 34300.0 | nM | 4.46 |
| CHEMBL390341 | — | IC50 | = | 35481.34 | nM | 4.45 |
| CHEMBL491309 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL491979 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL333137 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL525231 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL444521 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL514013 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL489938 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL375492 | AMITHIOZONE | IC50 | > | 50000.0 | nM | - |
| CHEMBL326294 | ISATIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL523111 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL493237 | — | IC50 | > | 50000.0 | nM | - |