Assay Detail
Binding
CHEMBL972641
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Inhibition of luciferin binding site of Photuris pennsylvanica luciferase by noncompetitive KinaseGlo luminescent assay
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Photuris pennsylvanica |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.98 | 5.30 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL512749 | — | — | 1 | 5.30 |
| CHEMBL460517 | — | — | 1 | 5.05 |
| CHEMBL460694 | — | — | 1 | 5.00 |
| CHEMBL405317 | — | — | 1 | 4.95 |
| CHEMBL460518 | — | — | 1 | 4.86 |
| CHEMBL473735 | — | — | 1 | 4.86 |
| CHEMBL472839 | — | — | 1 | 4.85 |
| CHEMBL472929 | — | — | 1 | - |
| CHEMBL514612 | — | — | 1 | - |
| CHEMBL472930 | — | — | 1 | - |
| CHEMBL472931 | — | — | 1 | - |
| CHEMBL473126 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL512749 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL460517 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL460694 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL405317 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL460518 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL473735 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL472839 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL472929 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL514612 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL472930 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL472931 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL473126 | — | Activity | - | — | - |