Assay Detail
Binding
CHEMBL972645
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Inhibition of luciferin binding site of Photuris pennsylvanica luciferase by competitive inhibition assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Photuris pennsylvanica |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.62 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92816 | — | — | 1 | 6.50 |
| CHEMBL460508 | — | — | 1 | 6.44 |
| CHEMBL508666 | — | — | 1 | 6.30 |
| CHEMBL460507 | — | — | 1 | 6.17 |
| CHEMBL490083 | — | — | 1 | 6.07 |
| CHEMBL507630 | — | — | 1 | 5.96 |
| CHEMBL449008 | — | — | 1 | 5.85 |
| CHEMBL462620 | — | — | 1 | 5.72 |
| CHEMBL201610 | — | — | 1 | 5.72 |
| CHEMBL462617 | — | — | 1 | 5.68 |
| CHEMBL328430 | — | — | 1 | 5.57 |
| CHEMBL129236 | — | — | 1 | 5.51 |
| CHEMBL453117 | — | — | 1 | 5.42 |
| CHEMBL460500 | — | — | 1 | 5.42 |
| CHEMBL511869 | — | — | 1 | 5.39 |
| CHEMBL460501 | — | — | 1 | 5.37 |
| CHEMBL453116 | — | — | 1 | 5.31 |
| CHEMBL452608 | — | — | 1 | 5.25 |
| CHEMBL512398 | — | — | 1 | 5.21 |
| CHEMBL499212 | — | — | 1 | 5.11 |
| CHEMBL506342 | — | — | 1 | 5.11 |
| CHEMBL462613 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92816 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL460508 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL508666 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL460507 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL490083 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL507630 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL449008 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL462620 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL201610 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL462617 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL328430 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL129236 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL453117 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL460500 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL511869 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL460501 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL453116 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL452608 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL512398 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL499212 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL506342 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL462613 | — | IC50 | = | 30000.0 | nM | 4.52 |