Assay Detail
Binding
CHEMBL972646
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Inhibition of luciferin binding site of Photinus pyralis luciferase by competitive inhibition assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Photinus pyralis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.54 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92816 | — | — | 1 | 6.70 |
| CHEMBL508666 | — | — | 1 | 6.22 |
| CHEMBL328430 | — | — | 1 | 6.16 |
| CHEMBL460508 | — | — | 1 | 6.00 |
| CHEMBL490083 | — | — | 1 | 5.89 |
| CHEMBL507630 | — | — | 1 | 5.82 |
| CHEMBL460507 | — | — | 1 | 5.82 |
| CHEMBL511869 | — | — | 1 | 5.66 |
| CHEMBL460500 | — | — | 1 | 5.55 |
| CHEMBL462620 | — | — | 1 | 5.54 |
| CHEMBL129236 | — | — | 1 | 5.52 |
| CHEMBL452608 | — | — | 1 | 5.50 |
| CHEMBL201610 | — | — | 1 | 5.50 |
| CHEMBL453117 | — | — | 1 | 5.46 |
| CHEMBL449008 | — | — | 1 | 5.35 |
| CHEMBL453116 | — | — | 1 | 5.27 |
| CHEMBL512398 | — | — | 1 | 5.24 |
| CHEMBL462617 | — | — | 1 | 5.20 |
| CHEMBL460501 | — | — | 1 | 5.05 |
| CHEMBL499212 | — | — | 1 | 4.95 |
| CHEMBL462613 | — | — | 1 | 4.87 |
| CHEMBL506342 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92816 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL508666 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL328430 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL460508 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL490083 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL507630 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL460507 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL511869 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL460500 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL462620 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL129236 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL452608 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL201610 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL453117 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL449008 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL453116 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL512398 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL462617 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL460501 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL499212 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL462613 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL506342 | — | IC50 | = | 24200.0 | nM | 4.62 |