Assay Detail
Binding
CHEMBL972652
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Inhibition of luciferin binding site of Photuris pennsylvanica luciferase by noncompetitive KinaseGlo Plus luminescent assay
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Photuris pennsylvanica |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.86 | 4.87 |
| Activity | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL512749 | — | — | 1 | 4.87 |
| CHEMBL460694 | — | — | 1 | 4.87 |
| CHEMBL460517 | — | — | 1 | 4.85 |
| CHEMBL460518 | — | — | 1 | - |
| CHEMBL472929 | — | — | 1 | - |
| CHEMBL473735 | — | — | 1 | - |
| CHEMBL405317 | — | — | 1 | - |
| CHEMBL472839 | — | — | 1 | - |
| CHEMBL473126 | — | — | 1 | - |
| CHEMBL472931 | — | — | 1 | - |
| CHEMBL472930 | — | — | 1 | - |
| CHEMBL514612 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL512749 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL460694 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL460517 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL460518 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL472929 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL473735 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL405317 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL472839 | — | Activity | - | — | - | |
| CHEMBL473126 | — | Activity | - | — | - | |
| CHEMBL472931 | — | Activity | - | — | - | |
| CHEMBL472930 | — | Activity | - | — | - | |
| CHEMBL514612 | — | Activity | - | — | - |