Assay Detail
Binding
CHEMBL972711
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Inhibition of p38alpha
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Targeting the ribose and phosphate binding site of p38 mitogen-activated protein (MAP) kinase: synthesis and biological testing of 2-alkylsulfanyl-, 4(5)-aryl-, 5(4)-heteroaryl-substituted imidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.57 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492296 | — | — | 1 | 8.70 |
| CHEMBL492255 | — | — | 1 | 8.70 |
| CHEMBL521637 | — | — | 1 | 8.52 |
| CHEMBL459716 | — | — | 1 | 8.52 |
| CHEMBL462265 | — | — | 1 | 8.52 |
| CHEMBL459926 | — | — | 1 | 8.52 |
| CHEMBL522486 | — | — | 1 | 8.40 |
| CHEMBL518628 | — | — | 1 | 8.30 |
| CHEMBL480962 | — | — | 1 | 8.30 |
| CHEMBL517287 | — | — | 1 | 8.22 |
| CHEMBL462477 | — | — | 1 | 8.00 |
| CHEMBL524174 | — | — | 1 | 7.96 |
| CHEMBL462476 | — | — | 1 | 7.92 |
| CHEMBL462679 | — | — | 1 | 7.89 |
| CHEMBL460773 | — | — | 1 | 7.82 |
| CHEMBL459934 | — | — | 1 | 7.75 |
| CHEMBL492295 | — | — | 1 | 7.72 |
| CHEMBL518367 | — | — | 1 | 7.57 |
| CHEMBL492264 | — | — | 1 | 7.44 |
| CHEMBL523494 | — | — | 1 | 7.43 |
| CHEMBL462462 | — | — | 1 | 7.39 |
| CHEMBL462463 | — | — | 1 | 7.06 |
| CHEMBL518492 | — | — | 1 | 6.99 |
| CHEMBL505334 | — | — | 1 | 6.80 |
| CHEMBL446739 | — | — | 1 | 6.74 |
| CHEMBL459737 | — | — | 1 | 6.67 |
| CHEMBL516468 | — | — | 1 | 6.41 |
| CHEMBL492463 | — | — | 1 | 6.40 |
| CHEMBL516620 | — | — | 1 | 6.31 |
| CHEMBL462494 | — | — | 1 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492296 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL492255 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL521637 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL459716 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL462265 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL459926 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL522486 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL518628 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL480962 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL517287 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL462477 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL524174 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL462476 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL462679 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL460773 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL459934 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL492295 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL518367 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL492264 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL523494 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL462462 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL462463 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL518492 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL505334 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL446739 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL459737 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL516468 | — | IC50 | = | 392.0 | nM | 6.41 |
| CHEMBL492463 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL516620 | — | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL462494 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL518798 | — | IC50 | = | 2240.0 | nM | 5.65 |