Assay Detail
Functional
CHEMBL972712
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Inhibition of LPS-stimulated TNFalpha release in human whole blood by ELISA
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting the ribose and phosphate binding site of p38 mitogen-activated protein (MAP) kinase: synthesis and biological testing of 2-alkylsulfanyl-, 4(5)-aryl-, 5(4)-heteroaryl-substituted imidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.96 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL524174 | — | — | 1 | 7.43 |
| CHEMBL492296 | — | — | 1 | 7.10 |
| CHEMBL462265 | — | — | 1 | 6.91 |
| CHEMBL459716 | — | — | 1 | 6.90 |
| CHEMBL521637 | — | — | 1 | 6.89 |
| CHEMBL459926 | — | — | 1 | 6.88 |
| CHEMBL462477 | — | — | 1 | 6.86 |
| CHEMBL462476 | — | — | 1 | 6.84 |
| CHEMBL518628 | — | — | 1 | 6.81 |
| CHEMBL492255 | — | — | 1 | 6.80 |
| CHEMBL462679 | — | — | 1 | 6.78 |
| CHEMBL459934 | — | — | 1 | 6.78 |
| CHEMBL517287 | — | — | 1 | 6.75 |
| CHEMBL460773 | — | — | 1 | 6.74 |
| CHEMBL480962 | — | — | 1 | 6.70 |
| CHEMBL518367 | — | — | 1 | 6.11 |
| CHEMBL462462 | — | — | 1 | 6.03 |
| CHEMBL462463 | — | — | 1 | 5.57 |
| CHEMBL516468 | — | — | 1 | 5.47 |
| CHEMBL446739 | — | — | 1 | 5.38 |
| CHEMBL518492 | — | — | 1 | 5.24 |
| CHEMBL459737 | — | — | 1 | 5.17 |
| CHEMBL492295 | — | — | 1 | 5.05 |
| CHEMBL522486 | — | — | 1 | 4.89 |
| CHEMBL492463 | — | — | 1 | 4.71 |
| CHEMBL518798 | — | — | 1 | 4.60 |
| CHEMBL505334 | — | — | 1 | 4.50 |
| CHEMBL516620 | — | — | 1 | 4.50 |
| CHEMBL492264 | — | — | 1 | 4.34 |
| CHEMBL523494 | — | — | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL524174 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL492296 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL462265 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL459716 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL521637 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL459926 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL462477 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL462476 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL518628 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL492255 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL462679 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL459934 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL517287 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL460773 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL480962 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL518367 | — | IC50 | = | 777.0 | nM | 6.11 |
| CHEMBL462462 | — | IC50 | = | 936.0 | nM | 6.03 |
| CHEMBL462463 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL516468 | — | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL446739 | — | IC50 | = | 4210.0 | nM | 5.38 |
| CHEMBL518492 | — | IC50 | = | 5724.0 | nM | 5.24 |
| CHEMBL459737 | — | IC50 | = | 6690.0 | nM | 5.17 |
| CHEMBL492295 | — | IC50 | = | 8940.0 | nM | 5.05 |
| CHEMBL522486 | — | IC50 | = | 12770.0 | nM | 4.89 |
| CHEMBL492463 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL518798 | — | IC50 | = | 25380.0 | nM | 4.60 |
| CHEMBL505334 | — | IC50 | = | 31930.0 | nM | 4.50 |
| CHEMBL516620 | — | IC50 | = | 31920.0 | nM | 4.50 |
| CHEMBL492264 | — | IC50 | = | 45480.0 | nM | 4.34 |
| CHEMBL523494 | — | IC50 | = | 65700.0 | nM | 4.18 |