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Assay Detail

CHEMBL972775

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human NCI-H187 cells by SRB assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NCI-H187
Confidence 1 — Organism
Curated By Autocuration

Target

NCI-H187 (CHEMBL2366276)
Type CELL-LINE
Organism Homo sapiens

Publication

19-Nor- and 18,20-epoxy-cardenolides from the leaves of Calotropis gigantea.
Lhinhatrakool T, Sutthivaiyakit S.
J Nat Prod (2006) 69 : 1249 -1251
PubMed 16933890 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 8 5.83 7.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 7.39
CHEMBL502127 CALACTIN 1 6.46
CHEMBL495949 CALOTROPIN 1 6.33
CHEMBL123 ELLIPTECINE 1 5.65
CHEMBL448177 1 5.48
CHEMBL509632 1 5.44
CHEMBL1453 DIGITOXIGENIN 1 5.01
CHEMBL499114 CALACTINICACID METHYL ESTER 1 4.84

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 40.5 nM 7.39
CHEMBL502127 CALACTIN IC50 = 345.0 nM 6.46
CHEMBL495949 CALOTROPIN IC50 = 471.0 nM 6.33
CHEMBL123 ELLIPTECINE IC50 = 2230.0 nM 5.65
CHEMBL448177 IC50 = 3330.0 nM 5.48
CHEMBL509632 IC50 = 3640.0 nM 5.44
CHEMBL1453 DIGITOXIGENIN IC50 = 9770.0 nM 5.01
CHEMBL499114 CALACTINICACID METHYL ESTER IC50 = 14400.0 nM 4.84