Assay Detail
Binding
CHEMBL972808
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PTP1B
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Protein tyrosine phosphatase-1B inhibitory activity of isoprenylated flavonoids isolated from Erythrina mildbraedii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.69 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | 5.44 |
| CHEMBL470865 | — | — | 1 | 4.83 |
| CHEMBL470454 | ABYSSINONE IV | — | 1 | 4.80 |
| CHEMBL470452 | — | — | 1 | 4.67 |
| CHEMBL470249 | — | — | 1 | 4.58 |
| CHEMBL470655 | SIGMOIDIN E | — | 1 | 4.41 |
| CHEMBL255890 | ABYSSINONE V | — | 1 | 4.40 |
| CHEMBL238628 | ALPINUMISOFLAVONE | — | 1 | 4.38 |
| CHEMBL426373 | — | — | 1 | - |
| CHEMBL513212 | — | — | 1 | - |
| CHEMBL182653 | — | — | 1 | - |
| CHEMBL129795 | ISOLIQUIRITIGENIN | — | 1 | - |
| CHEMBL252642 | LIQUIRTIGENIN | — | 1 | - |
| CHEMBL451532 | NARINGIN | — | 1 | - |
| CHEMBL445815 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169 | URSOLIC ACID | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL470865 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL470454 | ABYSSINONE IV | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL470452 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL470249 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL470655 | SIGMOIDIN E | IC50 | = | 39200.0 | nM | 4.41 |
| CHEMBL255890 | ABYSSINONE V | IC50 | = | 39700.0 | nM | 4.40 |
| CHEMBL238628 | ALPINUMISOFLAVONE | IC50 | = | 41500.0 | nM | 4.38 |
| CHEMBL426373 | — | IC50 | = | 4500.0 | nM | - |
| CHEMBL513212 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL182653 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL129795 | ISOLIQUIRITIGENIN | IC50 | > | 60000.0 | nM | - |
| CHEMBL252642 | LIQUIRTIGENIN | IC50 | > | 60000.0 | nM | - |
| CHEMBL451532 | NARINGIN | IC50 | > | 60000.0 | nM | - |
| CHEMBL445815 | — | IC50 | > | 60000.0 | nM | - |