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Assay Detail

CHEMBL972846

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Antiproliferative activity against HEK293 cells assessed as reduction of cell growth after 72 hrs by MTT method
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type HEK293
Confidence 1 — Organism
Curated By Autocuration

Target

HEK293 (CHEMBL614818)
Type CELL-LINE
Organism Homo sapiens

Publication

Antiproliferative triterpene saponins from Trevesia palmata.
De Tommasi N, Autore G, Bellino A, Pinto A, Pizza C, Sorrentino R, Venturella P.
J Nat Prod (2000) 63 : 308 -314
PubMed 10757708 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.87 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1425 MERCAPTOPURINE ANHYDROUS 4.0 1 8.15
CHEMBL505847 1 6.82
CHEMBL508634 1 6.77
CHEMBL506829 1 6.70
CHEMBL508736 1 6.50
CHEMBL501032 1 6.28
CHEMBL475806 1 -
CHEMBL506816 1 -
CHEMBL451591 1 -
CHEMBL503131 1 -
CHEMBL506550 1 -
CHEMBL501682 2 -
CHEMBL506880 HEDERASAPONIN B 1 -
CHEMBL502407 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1425 MERCAPTOPURINE ANHYDROUS IC50 = 7.0 nM 8.15
CHEMBL505847 IC50 = 150.0 nM 6.82
CHEMBL508634 IC50 = 170.0 nM 6.77
CHEMBL506829 IC50 = 200.0 nM 6.70
CHEMBL508736 IC50 = 320.0 nM 6.50
CHEMBL501032 IC50 = 520.0 nM 6.28
CHEMBL475806 IC50 - -
CHEMBL506816 IC50 - -
CHEMBL451591 IC50 - -
CHEMBL503131 IC50 - -
CHEMBL506550 IC50 - -
CHEMBL501682 IC50 - -
CHEMBL506880 HEDERASAPONIN B IC50 - -
CHEMBL502407 IC50 - -
CHEMBL501682 IC50 - -