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Assay Detail

CHEMBL972847

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Functional
Antiproliferative activity against mouse WEHI164 cells assessed as reduction of cell growth after 72 hrs by MTT method
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type WEHI-164
Confidence 1 — Organism
Curated By Autocuration

Target

WEHI-164 (CHEMBL614227)
Type CELL-LINE
Organism Mus musculus

Publication

Antiproliferative triterpene saponins from Trevesia palmata.
De Tommasi N, Autore G, Bellino A, Pinto A, Pizza C, Sorrentino R, Venturella P.
J Nat Prod (2000) 63 : 308 -314
PubMed 10757708 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.44 7.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1425 MERCAPTOPURINE ANHYDROUS 4.0 1 7.77
CHEMBL505847 1 6.62
CHEMBL508736 1 6.58
CHEMBL506880 HEDERASAPONIN B 1 6.22
CHEMBL501032 1 5.75
CHEMBL451591 1 5.72
CHEMBL508634 1 -
CHEMBL506816 1 -
CHEMBL475806 1 -
CHEMBL503131 1 -
CHEMBL506829 1 -
CHEMBL506550 1 -
CHEMBL501682 2 -
CHEMBL502407 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1425 MERCAPTOPURINE ANHYDROUS IC50 = 17.0 nM 7.77
CHEMBL505847 IC50 = 240.0 nM 6.62
CHEMBL508736 IC50 = 260.0 nM 6.58
CHEMBL506880 HEDERASAPONIN B IC50 = 600.0 nM 6.22
CHEMBL501032 IC50 = 1800.0 nM 5.75
CHEMBL451591 IC50 = 1900.0 nM 5.72
CHEMBL508634 IC50 - -
CHEMBL506816 IC50 - -
CHEMBL475806 IC50 - -
CHEMBL503131 IC50 - -
CHEMBL506829 IC50 - -
CHEMBL506550 IC50 - -
CHEMBL501682 IC50 - -
CHEMBL502407 IC50 - -
CHEMBL501682 IC50 - -