Assay Detail
Binding
CHEMBL973097
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDGFRbeta by cellular assay
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Platelet-derived growth factor receptor beta (CHEMBL1913) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 8.55 | 9.70 |
| EC50 | 2 | 8.22 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 9.70 |
| CHEMBL459850 | — | — | 1 | 8.22 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.39 |
| CHEMBL509032 | TAE-684 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL535 | SUNITINIB | Kd | = | 0.2 | nM | 9.70 |
| CHEMBL459850 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1336 | SORAFENIB | Kd | = | 41.0 | nM | 7.39 |
| CHEMBL509032 | TAE-684 | EC50 | > | 1000.0 | nM | - |