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Assay Detail

CHEMBL973253

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human Molt 4/C8 cells after 72 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Molt4/C8
Confidence 1 — Organism
Curated By Autocuration

Publication

Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells.
Perjési P, Das U, De Clercq E, Balzarini J, Kawase M, Sakagami H, Stables JP, Lorand T, Rozmer Z, Dimmock JR.
Eur J Med Chem (2008) 43 : 839 -845
PubMed 17692998 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.12 5.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL852 MELPHALAN 4.0 1 5.49
CHEMBL452006 1 5.28
CHEMBL451747 1 5.17
CHEMBL443096 1 5.12
CHEMBL455122 1 5.12
CHEMBL510057 1 5.11
CHEMBL451746 1 5.11
CHEMBL508286 1 5.11
CHEMBL509587 1 5.09
CHEMBL451745 1 5.09
CHEMBL452004 1 5.08
CHEMBL452001 1 4.92
CHEMBL511011 1 4.86

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL852 MELPHALAN IC50 = 3240.0 nM 5.49
CHEMBL452006 IC50 = 5220.0 nM 5.28
CHEMBL451747 IC50 = 6830.0 nM 5.17
CHEMBL443096 IC50 = 7610.0 nM 5.12
CHEMBL455122 IC50 = 7630.0 nM 5.12
CHEMBL510057 IC50 = 7700.0 nM 5.11
CHEMBL451746 IC50 = 7720.0 nM 5.11
CHEMBL508286 IC50 = 7750.0 nM 5.11
CHEMBL509587 IC50 = 8210.0 nM 5.09
CHEMBL451745 IC50 = 8110.0 nM 5.09
CHEMBL452004 IC50 = 8330.0 nM 5.08
CHEMBL452001 IC50 = 12000.0 nM 4.92
CHEMBL511011 IC50 = 13800.0 nM 4.86