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Assay Detail

CHEMBL973254

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human CEM cells after 72 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CCRF-CEM
Confidence 1 — Organism
Curated By Autocuration

Target

CCRF-CEM (CHEMBL382)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells.
Perjési P, Das U, De Clercq E, Balzarini J, Kawase M, Sakagami H, Stables JP, Lorand T, Rozmer Z, Dimmock JR.
Eur J Med Chem (2008) 43 : 839 -845
PubMed 17692998 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.09 5.61

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL852 MELPHALAN 4.0 1 5.61
CHEMBL452006 1 5.32
CHEMBL443096 1 5.10
CHEMBL451747 1 5.10
CHEMBL508286 1 5.10
CHEMBL451746 1 5.09
CHEMBL509587 1 5.08
CHEMBL452004 1 5.08
CHEMBL451745 1 5.07
CHEMBL510057 1 5.05
CHEMBL455122 1 4.94
CHEMBL511011 1 4.59
CHEMBL452001 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL852 MELPHALAN IC50 = 2470.0 nM 5.61
CHEMBL452006 IC50 = 4810.0 nM 5.32
CHEMBL443096 IC50 = 7940.0 nM 5.10
CHEMBL451747 IC50 = 7870.0 nM 5.10
CHEMBL508286 IC50 = 7920.0 nM 5.10
CHEMBL451746 IC50 = 8050.0 nM 5.09
CHEMBL509587 IC50 = 8300.0 nM 5.08
CHEMBL452004 IC50 = 8240.0 nM 5.08
CHEMBL451745 IC50 = 8430.0 nM 5.07
CHEMBL510057 IC50 = 8870.0 nM 5.05
CHEMBL455122 IC50 = 11600.0 nM 4.94
CHEMBL511011 IC50 = 25500.0 nM 4.59
CHEMBL452001 IC50 > 100000.0 nM -