Assay Detail
Functional
CHEMBL973273
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiprotozoal activity against Trypanosoma brucei rhodesiense STIB900
31
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Epimers of bicyclo[2.2.2]octan-2-ol derivatives with antiprotozoal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.56 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.41 |
| CHEMBL459423 | — | — | 2 | 6.21 |
| CHEMBL459437 | — | — | 2 | 6.07 |
| CHEMBL460449 | — | — | 2 | 6.02 |
| CHEMBL459436 | — | — | 2 | 5.97 |
| CHEMBL518332 | — | — | 2 | 5.95 |
| CHEMBL518167 | — | — | 2 | 5.84 |
| CHEMBL518622 | — | — | 2 | 5.82 |
| CHEMBL518623 | — | — | 2 | 5.78 |
| CHEMBL518333 | — | — | 2 | 5.75 |
| CHEMBL219419 | — | — | 2 | 5.60 |
| CHEMBL374245 | — | — | 2 | 5.53 |
| CHEMBL516462 | — | — | 2 | 5.51 |
| CHEMBL516624 | — | — | 2 | 5.47 |
| CHEMBL375980 | — | — | 2 | 5.27 |
| CHEMBL459424 | — | — | 2 | 4.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL459423 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL459437 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL460449 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL459436 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL459423 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL518332 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL518167 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL518622 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL518332 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL518623 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL518333 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL459436 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL219419 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL374245 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL516462 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL518623 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL516624 | — | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL518167 | — | IC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL374245 | — | IC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL219419 | — | IC50 | = | 4260.0 | nM | 5.37 |
| CHEMBL460449 | — | IC50 | = | 4950.0 | nM | 5.30 |
| CHEMBL375980 | — | IC50 | = | 5340.0 | nM | 5.27 |
| CHEMBL459437 | — | IC50 | = | 6270.0 | nM | 5.20 |
| CHEMBL375980 | — | IC50 | = | 13140.0 | nM | 4.88 |
| CHEMBL516462 | — | IC50 | = | 14990.0 | nM | 4.82 |
| CHEMBL518622 | — | IC50 | = | 15940.0 | nM | 4.80 |
| CHEMBL516624 | — | IC50 | = | 16920.0 | nM | 4.77 |
| CHEMBL518333 | — | IC50 | = | 37580.0 | nM | 4.42 |
| CHEMBL459424 | — | IC50 | = | 70940.0 | nM | 4.15 |
| CHEMBL459424 | — | IC50 | - | — | - |