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Assay Detail

CHEMBL973326

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to Saccharomyces cerevisiae Hst2 by isothermal titration calorimetry
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Saccharomyces cerevisiae
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

NAD-dependent protein deacetylase HST2 (CHEMBL5933)
Type SINGLE PROTEIN
Organism Saccharomyces cerevisiae S288c

Publication

Acetyl-lysine analog peptides as mechanistic probes of protein deacetylases.
Smith BC, Denu JM.
J Biol Chem (2007) 282 : 37256 -37265
PubMed 17951578 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 11 5.31 5.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1162221 1 5.48
CHEMBL500768 1 5.48
CHEMBL446124 1 5.48
CHEMBL1162220 1 5.48
CHEMBL525769 1 5.48
CHEMBL501380 1 5.48
CHEMBL500219 1 5.48
CHEMBL525757 1 5.48
CHEMBL450495 1 5.07
CHEMBL506659 1 4.80
CHEMBL507814 1 4.68

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1162221 Kd = 3300.0 nM 5.48
CHEMBL500768 Kd = 3300.0 nM 5.48
CHEMBL446124 Kd = 3300.0 nM 5.48
CHEMBL1162220 Kd = 3300.0 nM 5.48
CHEMBL525769 Kd = 3300.0 nM 5.48
CHEMBL501380 Kd = 3300.0 nM 5.48
CHEMBL500219 Kd = 3300.0 nM 5.48
CHEMBL525757 Kd = 3300.0 nM 5.48
CHEMBL450495 Kd = 8600.0 nM 5.07
CHEMBL506659 Kd = 16000.0 nM 4.80
CHEMBL507814 Kd = 21000.0 nM 4.68