Assay Detail

CHEMBL973328

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Binding

Inhibition of flag-tagged HDAC4

ChEMBL ↗

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Target

Histone deacetylase 4 (CHEMBL3524) ↗

Open DB target context

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Histone deacetylase 4 (CHEMBL3524) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Histone deacetylase 4

CHEMBL3524

Anchored from Assay target.

Protein identity Histone deacetylase 4

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Intermediate

Target

Histone deacetylase 4 (CHEMBL3524) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.

Lahm A, Paolini C, Pallaoro M, Nardi MC, Jones P, Neddermann P, Sambucini S, Bottomley MJ, Lo Surdo P, Carfí A, Koch U, De Francesco R, Steinkühler C, Gallinari P.
Proc Natl Acad Sci U S A (2007) 104 : 17335 -17340
PubMed 17956988 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.96	9.00

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL430060	APICIDIN	—	1	9.00
CHEMBL356066	DACINOSTAT	2.0	1	8.92

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL430060	APICIDIN	IC50	=	1.0	nM	9.00
CHEMBL356066	DACINOSTAT	IC50	=	1.2	nM	8.92