Assay Detail

CHEMBL973570

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Binding

Inhibition of Axl by radiometric assay

ChEMBL ↗

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Target

Tyrosine-protein kinase receptor UFO (CHEMBL4895) ↗

Open DB target context

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Tyrosine-protein kinase receptor UFO (CHEMBL4895) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Tyrosine-protein kinase receptor UFO

CHEMBL4895

Anchored from Assay target.

Protein identity Tyrosine-protein kinase receptor UFO

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Intermediate

Target

Tyrosine-protein kinase receptor UFO (CHEMBL4895) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Discovery of a potent and selective aurora kinase inhibitor.

Oslob JD, Romanowski MJ, Allen DA, Baskaran S, Bui M, Elling RA, Flanagan WM, Fung AD, Hanan EJ, Harris S, Heumann SA, Hoch U, Jacobs JW, Lam J, Lawrence CE, McDowell RS, Nannini MA, Shen W, Silverman JA, Sopko MM, Tangonan BT, Teague J, Yoburn JC, Yu CH, Zhong M, Zimmerman KM, O'Brien T, Lew W.
Bioorg Med Chem Lett (2008) 18 : 4880 -4884
PubMed 18678489 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.08	7.08

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL518051	SNS-314 MESYLATE	—	1	7.08

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL518051	SNS-314 MESYLATE	IC50	=	84.0	nM	7.08