Assay Detail
Binding
CHEMBL973601
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Binding affinity to human MC4 receptor
75
Total Activities
75
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies on a series of piperazinebenzylalcohols and their ketone and amine analogs as melanocortin-4 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 75 | 7.31 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487044 | — | — | 1 | 8.77 |
| CHEMBL365597 | — | — | 1 | 8.74 |
| CHEMBL505442 | — | — | 1 | 8.70 |
| CHEMBL487043 | — | — | 1 | 8.70 |
| CHEMBL511826 | — | — | 1 | 8.49 |
| CHEMBL488710 | — | — | 1 | 8.38 |
| CHEMBL488030 | — | — | 1 | 8.33 |
| CHEMBL462380 | — | — | 1 | 8.20 |
| CHEMBL528108 | — | — | 1 | 8.11 |
| CHEMBL513404 | — | — | 1 | 8.09 |
| CHEMBL471340 | — | — | 1 | 8.08 |
| CHEMBL454906 | — | — | 1 | 8.05 |
| CHEMBL454900 | — | — | 1 | 8.03 |
| CHEMBL454916 | — | — | 1 | 8.02 |
| CHEMBL454663 | — | — | 1 | 7.96 |
| CHEMBL508285 | — | — | 1 | 7.96 |
| CHEMBL366706 | — | — | 1 | 7.96 |
| CHEMBL471339 | — | — | 1 | 7.89 |
| CHEMBL508641 | — | — | 1 | 7.89 |
| CHEMBL462346 | — | — | 1 | 7.82 |
| CHEMBL512496 | — | — | 1 | 7.80 |
| CHEMBL454901 | — | — | 1 | 7.75 |
| CHEMBL471167 | — | — | 1 | 7.68 |
| CHEMBL462345 | — | — | 1 | 7.68 |
| CHEMBL447298 | — | — | 1 | 7.64 |
| CHEMBL460942 | — | — | 1 | 7.62 |
| CHEMBL528329 | — | — | 1 | 7.58 |
| CHEMBL514603 | — | — | 1 | 7.58 |
| CHEMBL454918 | — | — | 1 | 7.58 |
| CHEMBL509475 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487044 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL365597 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL487043 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL505442 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL511826 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL488710 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL488030 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL462380 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL528108 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL513404 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL471340 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL454906 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL454900 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL454916 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL366706 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL508285 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL454663 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL471339 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL508641 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL462346 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL512496 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL454901 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL471167 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL462345 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL447298 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL460942 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL514603 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL454918 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL528329 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL509475 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL488884 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL471517 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL508293 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL471516 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL452838 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL462009 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL471166 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL529449 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL454917 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL516659 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL519729 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL508284 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL455189 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL455188 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL213738 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL444749 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL462559 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL470301 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL472553 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL458329 | — | Ki | = | 110.0 | nM | 6.96 |