Assay Detail
Binding
CHEMBL973602
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Binding affinity to human MC4 receptor Asp122Ala mutant
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies on a series of piperazinebenzylalcohols and their ketone and amine analogs as melanocortin-4 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.61 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487044 | — | — | 1 | 7.00 |
| CHEMBL471517 | — | — | 1 | 6.54 |
| CHEMBL471340 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487044 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL471517 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL471340 | — | Ki | = | 500.0 | nM | 6.30 |