Assay Detail
Functional
CHEMBL973607
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human MC4 receptor expressed in cells assessed as inhibition of alpha-MSH-stimulated cAMP production
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies on a series of piperazinebenzylalcohols and their ketone and amine analogs as melanocortin-4 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.46 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL511826 | — | — | 1 | 6.60 |
| CHEMBL454916 | — | — | 1 | 6.60 |
| CHEMBL513404 | — | — | 1 | 6.58 |
| CHEMBL454900 | — | — | 1 | 6.40 |
| CHEMBL471340 | — | — | 1 | 6.38 |
| CHEMBL460942 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL511826 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL454916 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL513404 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL454900 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL471340 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL460942 | — | IC50 | = | 650.0 | nM | 6.19 |