Assay Detail

CHEMBL974183

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Functional

Cytotoxicity against human SH-SY5Y cells after 96 hrs by MTT assay

ChEMBL ↗

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Target

SH-SY5Y (CHEMBL614910) ↗

Open DB target context

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SH-SY5Y (CHEMBL614910) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target SH-SY5Y

CHEMBL614910

Anchored from Assay target.

Protein identity SH-SY5Y

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	SH-SY5Y
Confidence	1 — Organism
Curated By	Autocuration

Target

SH-SY5Y (CHEMBL614910) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Mycalamide D, a new cytotoxic amide from the New Zealand marine sponge Mycale species.

West LM, Northcote PT, Hood KA, Miller JH, Page MJ.
J Nat Prod (2000) 63 : 707 -709
PubMed 10843597 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.74	9.28

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL497451	MYCALAMIDE A	—	1	9.28
CHEMBL499036	MYCALAMIDE B	—	1	8.19

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL497451	MYCALAMIDE A	IC50	=	0.52	nM	9.28
CHEMBL499036	MYCALAMIDE B	IC50	=	6.42	nM	8.19