Assay Detail
Binding
CHEMBL974283
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat NMDA NR2A receptor expressed in xenopus oocytes coexpressing NMDA NR13b assessed as effect on glycine-induced current response at -70 mV by voltage clamp method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Oocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 2A (CHEMBL310) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.00 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2372184 | CONANTOKIN-R | — | 1 | 6.00 |
| CHEMBL524338 | — | — | 1 | - |
| CHEMBL525025 | CONANTOKIN G | — | 1 | - |
| CHEMBL526324 | — | — | 1 | - |
| CHEMBL525783 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2372184 | CONANTOKIN-R | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL524338 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL525025 | CONANTOKIN G | IC50 | > | 10000.0 | nM | - |
| CHEMBL526324 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL525783 | — | IC50 | > | 10000.0 | nM | - |