Compound Detail
CHEMBL525025
CONANTOKIN G Enter ChEMBL ID:
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CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C(=O)O)C(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C(=O)O)C(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C(=O)O)C(=O)O)NC(=O)[C@H](CC(C(=O)O)C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C(=O)O)C(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(N)=O
Basic Information
| ChEMBL ID | CHEMBL525025 |
| Name | CONANTOKIN G |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HTBKFGWATIYCSF-QGXIKSNHSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
2264.2
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 2B CHEMBL311 | IC50 | 7.0 | 7.0 | 100.0 | 1 |
| Glutamate receptor ionotropic, NMDA 2D CHEMBL303 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
| Glutamate receptor ionotropic, NMDA 2C CHEMBL401 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 2B | IC50 | = | 100.0 | nM | 7.0 | Inhibition of rat NMDA NR2B receptor expressed in xenopus oocytes coexpressing N... | 17962189 |
| Glutamate receptor ionotropic, NMDA 2C | IC50 | = | 1000.0 | nM | 6.0 | Inhibition of rat NMDA NR2C receptor expressed in xenopus oocytes coexpressing N... | 17962189 |
| Glutamate receptor ionotropic, NMDA 2D | IC50 | = | 1000.0 | nM | 6.0 | Inhibition of rat NMDA NR2D receptor expressed in xenopus oocytes coexpressing N... | 17962189 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17962189 | 10.1074/jbc.m706611200 | Glutamate receptor ionotropic, NMDA 2B | 2 |
| 17962189 | 10.1074/jbc.m706611200 | Unchecked | 2 |
| 17962189 | 10.1074/jbc.m706611200 | Glutamate receptor ionotropic, NMDA 2A | 1 |
| 17962189 | 10.1074/jbc.m706611200 | Glutamate receptor ionotropic, NMDA 2C | 1 |
| 17962189 | 10.1074/jbc.m706611200 | Glutamate receptor ionotropic, NMDA 2D | 1 |
Data from ChEMBL 36 via Core Engine