Assay Detail
Binding
CHEMBL974294
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Inhibition of human SGLT1 expressed in xenopus laevis oocyte assessed as inhibition of methyl-alpha-D-[14C]glucopyranoside uptake after 1 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tripeptides of RS1 (RSC1A1) inhibit a monosaccharide-dependent exocytotic pathway of Na+-D-glucose cotransporter SGLT1 with high affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.24 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL485830 | — | — | 1 | 9.80 |
| CHEMBL521026 | — | — | 1 | 9.77 |
| CHEMBL486028 | — | — | 1 | 8.70 |
| CHEMBL485831 | — | — | 1 | 8.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL485830 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL521026 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL486028 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL485831 | — | IC50 | = | 2.1 | nM | 8.68 |