Compound Detail
CHEMBL485831
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Basic Information
| ChEMBL ID | CHEMBL485831 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | QFTRCUPCARNIPZ-CIUDSAMLSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
346.4
MW (Da)
-1.93
ALogP
6
HBA
5
HBD
155.8
PSA (Ų)
0.32
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium/glucose cotransporter 1 CHEMBL4979 | IC50 | 8.68 | 8.68 | 2.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium/glucose cotransporter 1 | IC50 | = | 2.1 | nM | 8.68 | Inhibition of human SGLT1 expressed in xenopus laevis oocyte assessed as inhibit... | 17686765 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17686765 | 10.1074/jbc.m705416200 | Sodium/glucose cotransporter 1 | 9 |
Data from ChEMBL 36 via Core Engine