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Assay Detail

CHEMBL974332

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL ↗
216
Total Activities
109
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

C-C chemokine receptor type 5 (CHEMBL274) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Three-dimensional QSAR analyses of 1,3,4-trisubstituted pyrrolidine-based CCR5 receptor inhibitors.
Zhuo Y, Kong R, Cong XJ, Chen WZ, Wang CX.
Eur J Med Chem (2008) 43 : 2724 -2734
PubMed 18538451 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 216 8.53 10.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL21106 — — 2 10.22
CHEMBL316475 — — 2 10.00
CHEMBL20345 — — 2 10.00
CHEMBL320386 — — 1 10.00
CHEMBL319593 — — 2 9.70
CHEMBL21147 — — 2 9.70
CHEMBL99909 — — 2 9.70
CHEMBL20622 — — 2 9.70
CHEMBL520091 — — 2 9.64
CHEMBL511493 — — 2 9.64
CHEMBL480503 — — 2 9.54
CHEMBL21117 — — 2 9.52
CHEMBL455073 — — 2 9.52
CHEMBL480693 — — 2 9.47
CHEMBL464132 — — 2 9.40
CHEMBL20453 — — 2 9.40
CHEMBL471920 — — 2 9.30
CHEMBL278085 — — 1 9.30
CHEMBL513564 — — 2 9.29
CHEMBL500631 — — 2 9.24
CHEMBL472412 — — 2 9.22
CHEMBL520755 — — 2 9.17
CHEMBL318406 — — 2 9.15
CHEMBL471251 — — 2 9.12
CHEMBL101961 — — 2 9.10
CHEMBL281607 — — 2 9.10
CHEMBL511634 — — 2 9.10
CHEMBL471909 — — 2 9.10
CHEMBL172854 — — 2 9.10
CHEMBL470510 — — 2 9.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL21106 — IC50 = 0.05998 nM 10.22
CHEMBL21106 — IC50 = 0.06 nM 10.22
CHEMBL316475 — IC50 = 0.1 nM 10.00
CHEMBL20345 — IC50 = 0.1 nM 10.00
CHEMBL20345 — IC50 = 0.1 nM 10.00
CHEMBL316475 — IC50 = 0.1 nM 10.00
CHEMBL320386 — IC50 = 0.1 nM 10.00
CHEMBL319593 — IC50 = 0.2 nM 9.70
CHEMBL21147 — IC50 = 0.2 nM 9.70
CHEMBL20622 — IC50 = 0.2 nM 9.70
CHEMBL99909 — IC50 = 0.2 nM 9.70
CHEMBL99909 — IC50 = 0.2 nM 9.70
CHEMBL20622 — IC50 = 0.2 nM 9.70
CHEMBL21147 — IC50 = 0.2 nM 9.70
CHEMBL319593 — IC50 = 0.2 nM 9.70
CHEMBL511493 — IC50 = 0.23 nM 9.64
CHEMBL520091 — IC50 = 0.23 nM 9.64
CHEMBL520091 — IC50 = 0.2301 nM 9.64
CHEMBL511493 — IC50 = 0.2301 nM 9.64
CHEMBL480503 — IC50 = 0.29 nM 9.54
CHEMBL480503 — IC50 = 0.2897 nM 9.54
CHEMBL21117 — IC50 = 0.2999 nM 9.52
CHEMBL21117 — IC50 = 0.3 nM 9.52
CHEMBL455073 — IC50 = 0.2999 nM 9.52
CHEMBL455073 — IC50 = 0.3 nM 9.52
CHEMBL480693 — IC50 = 0.34 nM 9.47
CHEMBL480693 — IC50 = 0.3396 nM 9.47
CHEMBL464132 — IC50 = 0.3999 nM 9.40
CHEMBL20453 — IC50 = 0.4 nM 9.40
CHEMBL20453 — IC50 = 0.3999 nM 9.40
CHEMBL464132 — IC50 = 0.4 nM 9.40
CHEMBL278085 — IC50 = 0.5 nM 9.30
CHEMBL471920 — IC50 = 0.5 nM 9.30
CHEMBL471920 — IC50 = 0.5 nM 9.30
CHEMBL513564 — IC50 = 0.5105 nM 9.29
CHEMBL513564 — IC50 = 0.51 nM 9.29
CHEMBL500631 — IC50 = 0.57 nM 9.24
CHEMBL500631 — IC50 = 0.5702 nM 9.24
CHEMBL472412 — IC50 = 0.5998 nM 9.22
CHEMBL472412 — IC50 = 0.6 nM 9.22
CHEMBL520755 — IC50 = 0.67 nM 9.17
CHEMBL520755 — IC50 = 0.6699 nM 9.17
CHEMBL318406 — IC50 = 0.7 nM 9.15
CHEMBL318406 — IC50 = 0.6998 nM 9.15
CHEMBL471251 — IC50 = 0.7603 nM 9.12
CHEMBL471251 — IC50 = 0.76 nM 9.12
CHEMBL101961 — IC50 = 0.8 nM 9.10
CHEMBL172854 — IC50 = 0.7998 nM 9.10
CHEMBL511634 — IC50 = 0.7998 nM 9.10
CHEMBL471909 — IC50 = 0.7998 nM 9.10