Assay Detail
Binding
CHEMBL974341
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Inhibition of MMP1
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 54 | 5.81 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115653 | CIPEMASTAT | 2.0 | 1 | 8.64 |
| CHEMBL514138 | CGS-27023A | — | 1 | 7.38 |
| CHEMBL440498 | CTS-1027 | 2.0 | 1 | 6.45 |
| CHEMBL494823 | — | — | 1 | 6.19 |
| CHEMBL468739 | — | — | 1 | 6.17 |
| CHEMBL466052 | — | — | 1 | 6.11 |
| CHEMBL499159 | — | — | 1 | 6.02 |
| CHEMBL512237 | — | — | 1 | 5.89 |
| CHEMBL466237 | — | — | 1 | 5.76 |
| CHEMBL467459 | — | — | 1 | 5.70 |
| CHEMBL493177 | — | — | 1 | 5.64 |
| CHEMBL468738 | — | — | 1 | 5.49 |
| CHEMBL512061 | — | — | 1 | 5.47 |
| CHEMBL511729 | — | — | 1 | 5.44 |
| CHEMBL493178 | — | — | 1 | 5.38 |
| CHEMBL493989 | — | — | 1 | 5.37 |
| CHEMBL466059 | — | — | 1 | 5.34 |
| CHEMBL467460 | — | — | 1 | 5.20 |
| CHEMBL466249 | — | — | 1 | 5.18 |
| CHEMBL468731 | — | — | 1 | 5.15 |
| CHEMBL512275 | — | — | 1 | 5.03 |
| CHEMBL494824 | — | — | 1 | 4.89 |
| CHEMBL466060 | — | — | 1 | - |
| CHEMBL466461 | — | — | 1 | - |
| CHEMBL513823 | — | — | 1 | - |
| CHEMBL512613 | — | — | 1 | - |
| CHEMBL466208 | — | — | 1 | - |
| CHEMBL466045 | — | — | 1 | - |
| CHEMBL466656 | — | — | 1 | - |
| CHEMBL466657 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115653 | CIPEMASTAT | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL440498 | CTS-1027 | IC50 | = | 356.0 | nM | 6.45 |
| CHEMBL494823 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL468739 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL466052 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL499159 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL512237 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL466237 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL467459 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL493177 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL468738 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL512061 | — | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL511729 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL493178 | — | IC50 | = | 4180.0 | nM | 5.38 |
| CHEMBL493989 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL466059 | — | IC50 | = | 4540.0 | nM | 5.34 |
| CHEMBL467460 | — | IC50 | = | 6370.0 | nM | 5.20 |
| CHEMBL466249 | — | IC50 | = | 6560.0 | nM | 5.18 |
| CHEMBL468731 | — | IC50 | = | 7050.0 | nM | 5.15 |
| CHEMBL512275 | — | IC50 | = | 9330.0 | nM | 5.03 |
| CHEMBL494824 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL513148 | — | IC50 | - | — | - | |
| CHEMBL494167 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL466024 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL511433 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL469138 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL467262 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL468096 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL493179 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL492383 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL492384 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL466460 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL468095 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL467687 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL467482 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL468737 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL466625 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL513822 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL468708 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL466664 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL466663 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL466657 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL466656 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL466045 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL466208 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL512613 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL513823 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL466461 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL466060 | — | IC50 | > | 10000.0 | nM | - |