Assay Detail
Binding
CHEMBL974426
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Inhibition of verapamil-stimulated ATPase activity of mouse cysteine-less MDR3
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rhodamine inhibitors of P-glycoprotein: an amide/thioamide "switch" for ATPase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.09 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL490121 | — | — | 1 | 6.55 |
| CHEMBL524129 | — | — | 1 | 5.34 |
| CHEMBL523281 | — | — | 1 | 4.82 |
| CHEMBL490549 | — | — | 1 | 4.68 |
| CHEMBL493641 | — | — | 1 | 4.64 |
| CHEMBL495469 | — | — | 1 | 4.50 |
| CHEMBL491928 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL490121 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL524129 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL523281 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL490549 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL493641 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL495469 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL491928 | — | IC50 | > | 120000.0 | nM | - |