Assay Detail
Binding
CHEMBL974538
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Inhibition of human liver fructose-1,6-bisphosphatase in presence of fructose-2,6-bisphosphate
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Allosteric FBPase inhibitors gain 10(5) times in potency when simultaneously binding two neighboring AMP sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 7.28 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL462979 | — | — | 1 | 8.70 |
| CHEMBL462978 | — | — | 1 | 8.40 |
| CHEMBL457189 | — | — | 1 | 8.40 |
| CHEMBL457400 | — | — | 1 | 8.30 |
| CHEMBL463183 | — | — | 1 | 8.22 |
| CHEMBL515042 | — | — | 1 | 8.10 |
| CHEMBL456977 | — | — | 1 | 8.10 |
| CHEMBL515524 | — | — | 1 | 8.00 |
| CHEMBL456978 | — | — | 1 | 7.92 |
| CHEMBL458056 | — | — | 1 | 7.92 |
| CHEMBL456154 | — | — | 1 | 7.92 |
| CHEMBL456564 | — | — | 1 | 7.85 |
| CHEMBL456155 | — | — | 1 | 7.80 |
| CHEMBL456563 | — | — | 1 | 7.77 |
| CHEMBL514722 | — | — | 1 | 7.75 |
| CHEMBL456320 | — | — | 1 | 7.72 |
| CHEMBL456321 | — | — | 1 | 7.66 |
| CHEMBL455930 | — | — | 1 | 7.55 |
| CHEMBL458276 | — | — | 1 | 7.24 |
| CHEMBL456543 | — | — | 1 | 6.82 |
| CHEMBL456319 | — | — | 1 | 6.58 |
| CHEMBL516135 | — | — | 1 | 6.27 |
| CHEMBL459135 | — | — | 1 | 4.97 |
| CHEMBL457849 | — | — | 1 | 4.86 |
| CHEMBL498538 | — | — | 1 | 4.41 |
| CHEMBL459134 | — | — | 1 | 4.06 |
| CHEMBL496654 | — | — | 1 | - |
| CHEMBL496653 | — | — | 1 | - |
| CHEMBL458055 | — | — | 1 | - |
| CHEMBL456992 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL462979 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL462978 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL457189 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL457400 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL463183 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL515042 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL456977 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL515524 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL456978 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL458056 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL456154 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL456564 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL456155 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL456563 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL514722 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL456320 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL456321 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL455930 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL458276 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL456543 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL456319 | — | IC50 | = | 264.0 | nM | 6.58 |
| CHEMBL516135 | — | IC50 | = | 542.0 | nM | 6.27 |
| CHEMBL459135 | — | IC50 | = | 10589.0 | nM | 4.97 |
| CHEMBL457849 | — | IC50 | = | 13727.0 | nM | 4.86 |
| CHEMBL498538 | — | IC50 | = | 38530.0 | nM | 4.41 |
| CHEMBL459134 | — | IC50 | = | 86763.0 | nM | 4.06 |
| CHEMBL459023 | — | IC50 | - | — | - | |
| CHEMBL442729 | — | IC50 | - | — | - | |
| CHEMBL515525 | — | IC50 | - | — | - | |
| CHEMBL457848 | — | IC50 | - | — | - | |
| CHEMBL457834 | — | IC50 | - | — | - | |
| CHEMBL456542 | — | IC50 | - | — | - | |
| CHEMBL456541 | — | IC50 | - | — | - | |
| CHEMBL462980 | — | IC50 | - | — | - | |
| CHEMBL516144 | — | IC50 | - | — | - | |
| CHEMBL508325 | — | IC50 | - | — | - | |
| CHEMBL526294 | — | IC50 | - | — | - | |
| CHEMBL500269 | — | IC50 | = | 277143.0 | nM | - |
| CHEMBL456984 | — | IC50 | = | 134180.0 | nM | - |
| CHEMBL505578 | — | IC50 | = | 320180.0 | nM | - |
| CHEMBL456992 | — | IC50 | = | 234231.0 | nM | - |
| CHEMBL458055 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL496653 | — | IC50 | - | — | - | |
| CHEMBL496654 | — | IC50 | > | 100000.0 | nM | - |