Assay Detail
Binding
CHEMBL975083
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Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Halogenated boldine derivatives with enhanced monoamine receptor selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.18 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256075 | — | — | 1 | 8.52 |
| CHEMBL225853 | 3-BROMOBOLDINE | — | 1 | 7.18 |
| CHEMBL524439 | — | — | 1 | 7.09 |
| CHEMBL388564 | — | — | 1 | 6.69 |
| CHEMBL388342 | BOLDINE | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256075 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL225853 | 3-BROMOBOLDINE | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL524439 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL388564 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL388342 | BOLDINE | IC50 | = | 400.0 | nM | 6.40 |