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Assay Detail

CHEMBL975100

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV1 3B in H9 cells after 4 days by p24-antigen ELISA
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type H9
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora.
Chen M, Kilgore N, Lee KH, Chen DF.
J Nat Prod (2006) 69 : 1697 -1701
PubMed 17190445 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 9 5.20 7.64
Activity 3 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL129 ZIDOVUDINE 4.0 1 7.64
CHEMBL518108 1 5.62
CHEMBL251864 GOMISIN J 1 5.41
CHEMBL490125 SCHISANHENOL 1 5.24
CHEMBL522973 GOMISIN O 1 4.44
CHEMBL253907 TIGLOYLGOMISIN P 1 4.43
CHEMBL490308 SCHISANTHERIN B 1 4.40
CHEMBL521975 EPIGOMISIN O 1 4.38
CHEMBL490126 DEOXYSCHISANDRIN 1 -
CHEMBL463499 1 -
CHEMBL491342 ANGELOYLGOMISIN P 1 -
CHEMBL253688 SCHIZANDRIN 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL129 ZIDOVUDINE EC50 = 23.0 nM 7.64
CHEMBL518108 EC50 = 2400.0 nM 5.62
CHEMBL251864 GOMISIN J EC50 = 3900.0 nM 5.41
CHEMBL490125 SCHISANHENOL EC50 = 5700.0 nM 5.24
CHEMBL522973 GOMISIN O EC50 = 36000.0 nM 4.44
CHEMBL253907 TIGLOYLGOMISIN P EC50 = 37000.0 nM 4.43
CHEMBL490308 SCHISANTHERIN B EC50 = 40000.0 nM 4.40
CHEMBL521975 EPIGOMISIN O EC50 = 42000.0 nM 4.38
CHEMBL490126 DEOXYSCHISANDRIN Activity - -
CHEMBL463499 EC50 < 650.0 nM -
CHEMBL491342 ANGELOYLGOMISIN P Activity - -
CHEMBL253688 SCHIZANDRIN Activity - -