Assay Detail

CHEMBL975111

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Functional

Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay

ChEMBL ↗

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Target

MDA-MB-231 (CHEMBL400) ↗

Open DB target context

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MDA-MB-231 (CHEMBL400) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target MDA-MB-231

CHEMBL400

Anchored from Assay target.

Protein identity MDA-MB-231

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MDA-MB-231
Confidence	1 — Organism
Curated By	Autocuration

Target

MDA-MB-231 (CHEMBL400) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

seco-Cycloartane triterpenes from Gardenia aubryi.

Grougnet R, Magiatis P, Mitaku S, Loizou S, Moutsatsou P, Terzis A, Cabalion P, Tillequin F, Michel S.
J Nat Prod (2006) 69 : 1711 -1714
PubMed 17190447 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	4	5.64	6.60

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1563	DAUNORUBICIN HYDROCHLORIDE	4.0	1	6.60
CHEMBL2332132	SECAUBRYOLIDE	—	1	4.68
CHEMBL523126	SECAUBRYENOL	—	1	-
CHEMBL491709	SECAUBRYTRIOL	—	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1563	DAUNORUBICIN HYDROCHLORIDE	IC50	=	250.0	nM	6.60
CHEMBL2332132	SECAUBRYOLIDE	IC50	=	21000.0	nM	4.68
CHEMBL523126	SECAUBRYENOL	IC50	>	100000.0	nM	-
CHEMBL491709	SECAUBRYTRIOL	IC50	>	100000.0	nM	-